Journal article
Re‐engineering the Immune Response to Metastatic Cancer: Antibody‐Recruiting Small Molecules Targeting the Urokinase Receptor
Abstract
Developing selective strategies to treat metastatic cancers remains a significant challenge. Herein, we report the first antibody-recruiting small molecule (ARM) that is capable of recognizing the urokinase-type plasminogen activator receptor (uPAR), a uniquely overexpressed cancer cell-surface marker, and facilitating the immune-mediated destruction of cancer cells. A co-crystal structure of the ARM-U2/uPAR complex was obtained, representing …
Authors
Rullo AF; Fitzgerald KJ; Muthusamy V; Liu M; Yuan C; Huang M; Kim M; Cho AE; Spiegel DA
Journal
Angewandte Chemie International Edition, Vol. 55, No. 11, pp. 3642–3646
Publisher
Wiley
Publication Date
March 7, 2016
DOI
10.1002/anie.201510866
ISSN
1433-7851