Journal article
Anti-Thymocyte Globulin Prophylaxis Induces a Decrease in Naive Th Cells to Inhibit the Onset of Chronic Graft-versus-Host Disease: Results from the Canadian Bone Marrow Transplant Group (CBMTG) 0801 Study
Abstract
Anti-thymocyte globulin (ATG) is an established approach to decrease chronic GVHD (cGVHD), yet the exact mechanism is uncertain. To better understand the mechanism of action of ATG in preventing cGVHD, we evaluated the day 100 immune reconstitution of known cGVHD cellular biomarkers using patients from the randomized Canadian Bone Marrow Transplant Group (CBMTG) 0801 trial, which demonstrated a significant impact of ATG on cGVHD. In a separate …
Authors
Naeije L; Kariminia A; Abdossamadi S; Azadpour S; Subrt P; Kuzeljevic B; Irvine MA; Walker I; Schultz KR
Journal
Transplantation and Cellular Therapy, Vol. 26, No. 3, pp. 438–444
Publisher
Elsevier
Publication Date
March 2020
DOI
10.1016/j.bbmt.2019.11.015
ISSN
2666-6367