Journal article
Metabolic activation of 3-nitroperylene in the Salmonella/S9 assay
Abstract
The mutagenicity of 3-nitroperylene (nitroPer), a nitrated polycyclic aromatic hydrocarbon (PAH) has been extensively studied using the Ames Salmonella test. In accord with previous work, nitroPer proved to be a potent frameshift mutagen which requires activation by mixed function oxidases (MFOs) in the microsomes of rat liver S9 preparations. The concentration of S9 required for optimal activation of this mutagen is several times lower than …
Authors
Anderson JG; McCalla DR; Bryant DW; McCarry BE; Bromke AM
Journal
Mutagenesis, Vol. 2, No. 4, pp. 279–285
Publisher
Oxford University Press (OUP)
Publication Date
1987
DOI
10.1093/mutage/2.4.279
ISSN
0267-8357