Journal article
Can the RNA World Still Function without Cytidine?
Abstract
Most scenarios for the origin of life assume that RNA played a key role in both catalysis and information storage. The A, U, G, and C nucleobases in modern RNA all participate in secondary structure formation and replication. However, the rapid deamination of C to U and the absence of C in meteorite samples suggest that prebiotic RNA may have been deficient in cytosine. Here, we assess the ability of RNA sequences formed from a three-letter AUG …
Authors
Tupper AS; Pudritz RE; Higgs PG
Journal
Molecular Biology and Evolution, Vol. 37, No. 1, pp. 71–83
Publisher
Oxford University Press (OUP)
Publication Date
January 1, 2020
DOI
10.1093/molbev/msz200
ISSN
0737-4038