Journal article
A randomized, double-blind, window of opportunity trial evaluating the effects of chloroquine in breast cancer patients
Abstract
PurposeChloroquine has demonstrated anti-tumor activities through autophagy inhibition and cell cycle disruption. This study aimed to assess the effect of single-agent chloroquine on breast tumor cellular proliferation in a randomized, phase II, double-blind, placebo-controlled, pre-surgical window of opportunity trial.MethodsPatients with newly diagnosed breast cancer were randomized 2:1 to chloroquine 500 mg daily or placebo for 2- to 6-weeks …
Authors
Arnaout A; Robertson SJ; Pond GR; Lee H; Jeong A; Ianni L; Kroeger L; Hilton J; Coupland S; Gottlieb C
Journal
Breast Cancer Research and Treatment, Vol. 178, No. 2, pp. 327–335
Publisher
Springer Nature
Publication Date
November 2019
DOI
10.1007/s10549-019-05381-y
ISSN
0167-6806