Journal article
Characterization of Serotonin Signaling Components in Patients with Inflammatory Bowel Disease
Abstract
BACKGROUND: Tryptophan hydroxylase (TPH)1 catalyzes the biosynthesis of serotonin (5-hydroxytrptamine; 5-HT) in enterochromaffin (EC) cells, the predominant source of gut 5-HT. Secreted 5-HT regulates various gut functions through diverse 5-HT receptor (5-HTR) families, and 5-HT transporter (5-HTT) sequesters its activity via uptake into surrounding cells. In inflammatory bowel disease (IBD) mucosal 5-HT signaling is altered, including …
Authors
Shajib S; Chauhan U; Adeeb S; Chetty Y; Armstrong D; Halder SLS; Marshall JK; Khan WI
Journal
Journal of the Canadian Association of Gastroenterology, Vol. 2, No. 3, pp. 132–140
Publisher
Oxford University Press (OUP)
Publication Date
July 10, 2019
DOI
10.1093/jcag/gwy039
ISSN
2515-2084