Journal article
Digoxin–mortality: randomized vs. observational comparison in the DIG trial
Abstract
AIMS: The Digitalis Investigation Group (DIG) trial, the only large randomized trial of digoxin in heart failure, reported a neutral effect on mortality and a significant reduction in heart failure hospitalizations. Recent observational studies reported increased mortality with digoxin treatment. We present further analyses of the DIG trial displaying the inability to control bias in observational treatment comparisons despite extensive …
Authors
Dávila LA; Weber K; Bavendiek U; Bauersachs J; Wittes J; Yusuf S; Koch A
Journal
European Heart Journal, Vol. 40, No. 40, pp. 3336–3341
Publisher
Oxford University Press (OUP)
Publication Date
October 21, 2019
DOI
10.1093/eurheartj/ehz395
ISSN
0195-668X