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Paraspinal muscle ladybird homeobox 1 (LBX1) in...
Journal article

Paraspinal muscle ladybird homeobox 1 (LBX1) in adolescent idiopathic scoliosis: a cross-sectional study

Abstract

BACKGROUND CONTEXT: Adolescent idiopathic scoliosis (AIS) is the leading cause of spinal deformity in adolescents globally. Recent evidence from genome-wide association studies has implicated variants in or near the ladybird homeobox 1 (LBX1) gene, encoding the ladybird homeobox 1 transcription factor, in AIS development. This gene plays a critical role in guiding embryonic neurogenesis and myogenesis and is vital in muscle mass determination. …

Authors

Jennings W; Hou M; Perterson D; Missiuna P; Thabane L; Tarnopolsky M; Samaan MC

Journal

The Spine Journal, Vol. 19, No. 12, pp. 1911–1916

Publisher

Elsevier

Publication Date

December 2019

DOI

10.1016/j.spinee.2019.06.014

ISSN

1529-9430