Development of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Summary of Findings (SoF) Table for Network Meta-analysis
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OBJECTIVE: To develop a Grading of Recommendations, Assessment, Development and Evaluation (GRADE) summary of findings (SoF) table format that displays the critical information from a network meta-analysis (NMA). STUDY DESIGN AND SETTING: We applied a user experience model for data analysis based on four rounds of semi-structured interviews. RESULTS: We interviewed thirty-two stakeholders who conduct or use meta-analyses (MA). Four rounds of interviews produced six candidate NMA-SoF tables. Users found highly acceptable a final NMA-SoF table that included the following components: 1) details of the clinical question (PICO), 2) a plot depicting network geometry, 3) relative and absolute effect estimates, 4) certainty of evidence, 5) ranking of treatments, and 6) interpretation of findings. CONCLUSION: Using stakeholder feedback, we developed a new GRADE NMA-SoF table that includes relevant components for understanding NMA findings and health decision-making.
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