Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise Academic Article uri icon

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abstract

  • Objective.To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials.Methods.A Delphi survey including 99 items was circulated among international experts for 3 rounds.Results.Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging.Conclusion.This study highlights similarities and differences in experts’ perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

publication date

  • December 2017