Journal article
Determining the cause of patchwork HBA1 and HBA2 genes: recurrent gene conversion or crossing over fixation events.
Abstract
BACKGROUND AND OBJECTIVES: Recombinations are common between the two homologous alpha-globin genes. We report on the identification and characterization of two patchwork alpha-globin genes.
DESIGN AND METHODS: Multiplex polymerase chain reaction assays were performed to rule out the presence of alpha-globin gene deletions and triplications. The HBA1 (alpha1-globin) and HBA2 (alpha2-globin) genes were individually amplified and sequenced.
Authors
Law H-Y; Luo H-Y; Wang W; Ho JFV; Najmabadi H; Ng ISL; Steinberg MH; Chui DHK; Chong SS
Journal
Haematologica, Vol. 91, No. 3, pp. 297–302
Publication Date
March 2006
ISSN
0390-6078