The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation Journal Articles

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abstract

Key Points This breakthrough involves the role of the aryl hydrocarbon receptor in the expansion and specification of hematopoietic progenitor cells. This work sets a precedent for the use of an in vitro platform for the clinically relevant production of blood products.

authors

Smith, Brenden W
Rozelle, Sarah S
Leung, Amy
Ubellacker, Jessalyn
Parks, Ashley
Nah, Shirley K
French, Deborah
Gadue, Paul
Monti, Stefano
Chui, David Hing-kwei
Steinberg, Martin H
Frelinger, Andrew L
Michelson, Alan D
Theberge, Roger
McComb, Mark E
Costello, Catherine E
Kotton, Darrell N
Mostoslavsky, Gustavo
Sherr, David H
Murphy, George J

status

published

publication date

July 18, 2013

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Animals (MeSH)
Apoptosis (MeSH)
Aryl Hydrocarbon Hydroxylases (MeSH)
Carbazoles (MeSH)
Cell Differentiation (MeSH)
Cell Lineage (MeSH)
Cell Proliferation (MeSH)
Cytochrome P-450 CYP1B1 (MeSH)
Erythroid Cells (MeSH)
Feeder Cells (MeSH)
Gene Expression Regulation, Enzymologic (MeSH)
Genome, Human (MeSH)
Hematopoietic Stem Cells (MeSH)
Humans (MeSH)
Immunology (Science Metrix)
Induced Pluripotent Stem Cells (MeSH)
Megakaryocytes (MeSH)
Mice (MeSH)
Receptors, Aryl Hydrocarbon (MeSH)

published in

Blood Journal