Immune Activation and Neuropsychiatric Symptoms in HIV Infection Journal Articles uri icon

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  • This study examined the role of biological processes in the development of specific neuropsychiatric complications in HAART-naive adults with HIV/AIDS. Depressive symptoms were modestly associated with elevated IL-6 mRNA expression (r(s)=0.40, p<0.05) even after removing the influences of other subjective complaints (pr=0.39, p<0.05). Elevated serum neopterin was strongly associated with depressive symptoms in individuals taking antidepressants (r(s)=0.83, p<0.001), though the association was nullified in those not on antidepressants (r(s)=-0.25, p>0.05). Mean neopterin levels were higher in the depressed as compared with nondepressed group but only for those taking antidepressants (F=45.66, df=1, 11, p<0.001). Neuropsychological impairment was not associated with the biological markers. These findings suggest that systemic immune markers (like neopterin) may be useful in differentiating treatment-resistant individuals at greater risk of developing chronic depression.


  • Warriner, Erin
  • Rourke, Sean B
  • Rourke, Byron P
  • Rubenstein, Sarah
  • Millikin, Colleen
  • Buchanan, Lori
  • Connelly, Phil
  • Hyrcza, Martin
  • Ostrowski, Mario
  • Der, Sandy
  • Gough, Kevin

publication date

  • July 2010