Secondary depression in panic disorder and agoraphobia. II. Dimensions of depressive symptomatology and their response to treatment Academic Article uri icon

  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All


  • Secondary depressive symptomatology in 435 subjects with panic disorder and phobic avoidance was studied before and after alprazolam treatment. No subject who had a primary affective disorder was included. Calculation of Hamilton Depression Rating Scale factor scores revealed that the agitation/anxiety, sleep disturbance, and somatization factors accounted for approximately 75% of the HAM-D total score; these all showed significant improvement with alprazolam treatment. There were few differences in dimensions of depressive symptomatology between those subjects with and those without major depression; the main difference was in the overall intensity of the depression.


  • Lesser, Ira M
  • Rubin, Robert T
  • Rifkin, Arthur
  • Swinson, Richard
  • Ballenger, James C
  • Burrows, Graham D
  • Dupont, Robert L
  • Noyes, Russell
  • Pecknold, John C

publication date

  • January 1989