Journal article
Host-Specific Adaptive Diversification of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli
Abstract
Crohn's disease (CD) is an inflammatory bowel disease influenced by bacteria. Adherent-invasive E. coli (AIEC) is associated with CD, yet the adaptations facilitating AIEC gut colonization are unknown. AIEC isolates exhibit high genetic diversity, suggesting strains evolve independently across different gut environments. We tracked the adaptive evolution of AIEC in a murine model of chronic colonization across multiple hosts and transmission …
Authors
Elhenawy W; Tsai CN; Coombes BK
Journal
Cell Host & Microbe, Vol. 25, No. 2, pp. 301–312.e5
Publisher
Elsevier
Publication Date
February 2019
DOI
10.1016/j.chom.2018.12.010
ISSN
1931-3128