Current Thoughts on the Use of Methotrexate in Patients with Psoriasis Academic Article uri icon

  •  
  • Overview
  •  
  • Identity
  •  
  • Additional Document Info
  •  
  • View All
  •  

abstract

  • Background: There are many problems associated with the use of methotrexate in the treatment of psoriasis. Objective: We will attempt to assist the clinician in resolving some of these problems. Methods: This article is a summary of a Round Table Discussion on methotrexate held at the Canadian Dermatology Association meeting at Whistler, BC, July 1995; of a Continuing Medical Education meeting on methotrexate at Langdon Hall, Cambridge, ON, May 1996; and our review of the pertinent literature. Results: We recommend routine folic acid supplementation in patients receiving methotrexate. A baseline pretreatment liver biopsy is probably not indicated in patients without clinical or laboratory evidence of liver disease; and patients on 15 mg or less of methotrexate per week with normal liver function may not need liver biopsy. Conclusion: Liver biopsy of patients on methotrexate for psoriasis may not be necessary.

publication date

  • July 1997