Journal article
Functional Roles for C5a and C5aR but Not C5L2 in the Pathogenesis of Human and Experimental Cerebral Malaria
Abstract
The host immune response plays an important role in the onset and progression of cerebral malaria (CM). The complement system is an essential component of the innate immune response to malaria, and its activation generates the anaphylatoxin C5a. To test the hypothesis that C5a signaling contributes to the pathogenesis of CM, we investigated a causal role for the C5a receptors C5aR and C5L2 in a mouse model of experimental CM (ECM) induced by …
Authors
Kim H; Erdman LK; Lu Z; Serghides L; Zhong K; Dhabangi A; Musoke C; Gerard C; Cserti-Gazdewich C; Liles WC
Journal
Infection and Immunity, Vol. 82, No. 1, pp. 371–379
Publisher
American Society for Microbiology
Publication Date
1 2014
DOI
10.1128/iai.01246-13
ISSN
0019-9567