Considering Type 1 Diabetes as a Form of Accelerated Muscle Aging Journal Articles

abstract

• Recent evidence reveals impairments to skeletal muscle health in adolescent/young adults with type 1 diabetes (T1D). Interestingly, the observed changes in T1D are not unlike aged muscle, particularly, the alterations to mitochondria. Thus, we put forth the novel hypothesis that T1D may be considered a condition of accelerated muscle aging and that, similar to aging, mitochondrial dysfunction is a primary contributor to this complication.

authors

• Monaco, Cynthia MF
• Gingrich, Molly A
• Hawke, Thomas

status

• published 

publication date

• April 2019

has subject area

• 0913 Mechanical Engineering (FoR)
• 1106 Human Movement and Sports Sciences (FoR)
• 1116 Medical Physiology (FoR)
• Aging (MeSH)
• Diabetes Mellitus, Type 1 (MeSH)
• Humans (MeSH)
• Mitochondria, Muscle (MeSH)
• Muscle, Skeletal (MeSH)
• Oxidative Stress (MeSH)
• Reactive Oxygen Species (MeSH)
• Sport Sciences (Science Metrix)

published in

• Exercise and Sport Sciences Reviews  Journal

keywords

• Aging
• Diabetes Mellitus, Type 1
• Humans
• Mitochondria, Muscle
• Muscle, Skeletal
• Oxidative Stress
• Reactive Oxygen Species

Digital Object Identifier (DOI)

• 10.1249/jes.0000000000000184

PubMed ID

• 30653028

start page

• 98

end page

• 107

volume

• 47

issue

• 2