Bacterial Adhesion Forces with Substratum Surfaces and the Susceptibility of Biofilms to Antibiotics Academic Article uri icon

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abstract

  • ABSTRACTBiofilms causing biomaterial-associated infection resist antibiotic treatment and usually necessitate the replacement of infected implants. Here we relate bacterial adhesion forces and the antibiotic susceptibility of biofilms on uncoated and polymer brush-coated silicone rubber. Nine strains ofStaphylococcus aureus,Staphylococcus epidermidis, andPseudomonas aeruginosaadhered more weakly to brush-coated silicone rubber (−0.05 ± 0.03 to −0.51 ± 0.62 nN) than to uncoated silicone rubber (−1.05 ± 0.46 to −5.1 ± 1.3 nN). Biofilms of weakly adhering organisms on polymer brush coatings remained in a planktonic state, susceptible to gentamicin, unlike biofilms formed on uncoated silicone rubber.

authors

  • Muszanska, Agnieszka K
  • Nejadnik, M Reza
  • Chen, Yun
  • Van den Heuvel, Edwin
  • Busscher, Henk J
  • van der Mei, Henny C
  • Norde, Willem

publication date

  • September 2012