Journal article
Effects of blood pressure lowering on cardiovascular events, in the context of regression to the mean
Abstract
OBJECTIVE: To assess the clinical relevance of regression to the mean for clinical trials and clinical practice.
METHODS: MEDLINE was searched until February 2018 for randomized trials of BP lowering with over 1000 patient-years follow-up per group. We estimated baseline mean BP, follow-up mean (usual) BP amongst patients grouped by 10 mmHg strata of baseline BP, and assessed effects of BP lowering on coronary heart disease (CHD) and stroke …
Authors
Salam A; Atkins E; Sundström J; Hirakawa Y; Ettehad D; Emdin C; Neal B; Woodward M; Chalmers J; Berge E
Journal
Journal of Hypertension, Vol. 37, No. 1, pp. 16–23
Publisher
Wolters Kluwer
Publication Date
January 2019
DOI
10.1097/hjh.0000000000001994
ISSN
0263-6352