Journal article
Rivaroxaban versus standard anticoagulation for acute venous thromboembolism in childhood. Design of the EINSTEIN-Jr phase III study
Abstract
BackgroundVenous thromboembolism (VTE) is a relatively rare condition in childhood with treatment mainly based on extrapolation from studies in adults. Therefore, clinical trials of anticoagulation in children require novel approaches to deal with numerous challenges. The EINSTEIN-Jr program identified pediatric rivaroxaban regimens commencing with in vitro dose finding studies followed by evaluation of children of different ages through phase …
Authors
Lensing AWA; Male C; Young G; Kubitza D; Kenet G; Patricia Massicotte M; Chan A; Molinari AC; Nowak-Goettl U; Pap ÁF
Journal
Thrombosis Journal, Vol. 16, No. 1,
Publisher
Springer Nature
Publication Date
December 2018
DOI
10.1186/s12959-018-0188-y
ISSN
1477-9560