Journal article
The Impact of Excluding Patients with End-Stage Knee Disease in Intra-Articular Hyaluronic Acid Trials: A Systematic Review and Meta-Analysis
Abstract
IntroductionThe Kellgren–Lawrence (K–L) grade is the most commonly used measure of radiographic disease severity in knee osteoarthritis (OA). Studies suggest that intra-articular hyaluronic acid (IA-HA) should only be considered in cases of early stage knee OA. The purpose of this review was to determine if trials administering IA-HA in early-moderate knee OA patients demonstrated greater pain relief than studies that also included patients …
Authors
Nicholls M; Shaw P; Niazi F; Bhandari M; Bedi A
Journal
Advances in Therapy, Vol. 36, No. 1, pp. 147–161
Publisher
Springer Nature
Publication Date
January 2019
DOI
10.1007/s12325-018-0847-1
ISSN
0741-238X