The objective of this study is to refine the Patient’s Perception of Hemodialysis Scale and data quality and refine the Patient’s Perception of Life on Hemodialysis Scale (PPHS). Collecting data from a convenient sample ( N = 236), data were collected and a cross-sectional design survey design was used. Item inclusion was based on the item’s theoretical underpinning, examination of data quality, findings from a multi-trait/multi-item correlation matrix, and criteria for item and scale characteristics. Data indicators were close to normal in terms of distribution. High and low statistics suggest that the entire scope of the characteristic being measured were experienced. All criteria related to this examination supported the inclusion/exclusion of remaining items and subscales. Subscales are able to measure the main concepts. Findings from this research have been analyzed, and the PPHS now includes five subscales (36 items) and is deemed a valid indicator of the hemodialysis patients’ perceptions of life. Nephrology nurses will be able to assess the patient’s illness and treatment experience, their perception of formal social supports, adjustment to life on hemodialysis, and design interventions.