abstract
- Download Citation on ResearchGate \textbar Thromboxane A2 causes feedback amplification involving extensive thromboxane A2 formation on close contact of human platelets in media with low concentration of ionized calcium \textbar Close platelet-to-platelet contact induced by weak agonists in a medium with a low concentration of Ca2+ leads to thromboxane A2 (TXA2) formation, release of granule contents, and secondary aggregation. These responses do not occur in a medium containing Ca2+ in the... \vphantom