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A tyrosine sulfation–dependent HLA-I modification...
Journal article

A tyrosine sulfation–dependent HLA-I modification identifies memory B cells and plasma cells

Abstract

Memory B cells and plasma cells are antigen-experienced cells tasked with the maintenance of humoral protection. Despite these prominent functions, definitive cell surface markers have not been identified for these cells. We report here the isolation and characterization of the monoclonal variable lymphocyte receptor B (VLRB) N8 antibody from the evolutionarily distant sea lamprey that specifically recognizes memory B cells and plasma cells in …

Authors

Chan JTH; Liu Y; Khan S; St-Germain JR; Zou C; Leung LYT; Yang J; Shi M; Grunebaum E; Campisi P

Journal

Science Advances, Vol. 4, No. 11,

Publisher

American Association for the Advancement of Science (AAAS)

Publication Date

November 2, 2018

DOI

10.1126/sciadv.aar7653

ISSN

2375-2548