Journal article
The Fragility and Reliability of Conclusions of Anesthesia and Critical Care Randomized Trials With Statistically Significant Findings
Abstract
OBJECTIVES: The Fragility Index, which represents the number of patients responsible for a statistically significant finding, has been suggested as an aid for interpreting the robustness of results from clinical trials. A small Fragility Index indicates that the statistical significance of a trial depends on only a few events. Our objectives were to calculate the Fragility Index of statistically significant results from randomized controlled …
Authors
Grolleau F; Collins GS; Smarandache A; Pirracchio R; Gakuba C; Boutron I; Busse JW; Devereaux PJ; Le Manach Y
Journal
Critical Care Medicine, Vol. 47, No. 3, pp. 456–462
Publisher
Wolters Kluwer
Publication Date
March 2019
DOI
10.1097/ccm.0000000000003527
ISSN
0090-3493