Clinical comparison of three polyhexanide-preserved multi-purpose contact lens solutions

This study investigated the clinical differences between three commercially available polyhexanide (PHMB) preserved disinfection systems containing varying percentages of PHMB, when used with FDA group II and group IV disposable contact lenses. After 1 month of wear the product with the highest concentration of PHMB ('All-in-One') was graded as being less comfortable on insertion (P<0.003), had lower overall satisfaction (P<0.05) when compared with the other two products. Corneal staining was also significantly higher with this product after both 14 days (P<0.001 with group II and P<0.02 with group IV) and 28 days (P<0.00001 with group II and P<0.03 ith group IV).