Persistently HIV-1 Seronegative Nairobi Sex Workers Are Susceptible to In Vitro Infection Academic Article uri icon

  •  
  • Overview
  •  
  • Research
  •  
  • Identity
  •  
  • Additional Document Info
  •  
  • View All
  •  

abstract

  • OBJECTIVE: To evaluate whether resistance to HIV-1 infection in a subset of highly exposed sex workers correlates with resistance at the cellular level.DESIGN: In vitro evaluation of susceptibility to infection by Kenyan HIV-1 isolates and cellular production of potential mediators of resistance.SETTING: Samples were collected in a primary care clinic in Nairobi.PATIENTS: Thirteen individuals from a cohort of sex workers with a similar risk of acquiring HIV infection and six unexposed controls.INTERVENTIONS: Subjects were provided with appropriate primary care and counselling on the prevention of sexually transmitted diseases.RESULTS: No inherent cellular resistance to infection was identified. CD8+cells from a subset of subjects strongly inhibited viral replication.CONCLUSIONS: Lack of infection in this cohort was not attributable to factors inherent to CD4+cells. Resistance to HIV infection is likely to be multifactorial, and products of CD8+cells and unique features of mucosal sites probably contribute to this state.

authors

  • Bienzle, Dorothee
  • MacDonald, Kelly S
  • Copeland, Karen FT
  • Bwayo, Job J
  • Plummer, Francis A
  • Rosenthal, Kenneth

publication date

  • 2000