Investigation of RNA structure-switching aptamers in tunable sol–gel-derived materials

In recent years RNA aptamers have emerged as potential recognition elements for solid phase assays, including assays that utilize sol–gel based biohybrid materials. However, there is still very little knowledge regarding the behavior of RNA aptamers when entrapped in sol–gel-derived materials. In this work, we evaluated the performance of an adenosine triphosphate (ATP)-binding structure-switching RNA aptamer in a series of sol–gel derived …