Journal article
Lack of effect of leukotriene D4 on Ca‐uptake in airway smooth muscle
Abstract
The effects of verapamil on leukotriene D4 (LTD4)- and KCl-induced contractions and 45Ca-uptake were examined in guinea-pig isolated tracheal smooth muscle. Both LTD4 (0.1 to 200 nmol l-1) and KCl (8 to 125 mmol l-1) produced concentration-dependent increases in tension in the tracheal preparations. Verapamil (1 mumol l-1) inhibited the tension responses induced by both LTD4 and KCl. LTD4 failed to increase the lanthanum-resistant Ca content of …
Authors
Raeburn D; Rodger IW
Journal
British Journal of Pharmacology, Vol. 83, No. 2, pp. 499–504
Publisher
Wiley
Publication Date
October 1984
DOI
10.1111/j.1476-5381.1984.tb16513.x
ISSN
0007-1188