Journal article
The effect of M&B 22948 on methacholine‐ and histamine‐induced contraction and inositol 1,4,5‐trisphosphate levels in guinea‐pig tracheal tissue
Abstract
The effect of a cyclic GMP phosphodiesterase inhibitor, M&B 22948, on methacholine- and histamine-induced contraction and inositol 1,4,5-trisphosphate (IP3) elevation was studied in guinea-pig tracheal rings. After addition of methacholine or histamine the rise in IP3 content was rapid and transient reaching a maximum after 5-15 s, which coincided with the maximum rate of tension development. Cyclic GMP levels of the tissue were elevated by M&B …
Authors
Langlands JM; Rodger IW; Diamond J
Journal
British Journal of Pharmacology, Vol. 98, No. 2, pp. 336–338
Publisher
Wiley
Publication Date
October 1989
DOI
10.1111/j.1476-5381.1989.tb12600.x
ISSN
0007-1188