Ouabain-insensitive, halide-sensitive Tl+ uptake by canine iliac arteries

Ouabain-insensitive Tl+ uptake by canine iliac arteries was studied. A significant fraction was halide-sensitive, with Br- substituting well for Cl-. The halide-sensitive component was inhibited by diuretics (MK196, bumetanide), PCMBS, low temperatures and external cations K+, Rb+. External but not internal Na+ was necessary for the uptake process. The process was not sensitive to disulphonic stilbenes. The halide-sensitive uptake appears to represent the operation of a (Na+/K+/Cl-)-cotransport process in arteries.