Pulmonary edema associated with isoxsuprine therapy

A 0.5% incidence of pulmonary edema was observed when the records of 1,407 patients treated with parenteral isoxsuprine over a 7-year interval were reviewed. Drug infusion rates were within the normal range in the seven affected patients. Discontinuation of therapy, oxygenation, and the administration of diuretics with or without digoxin were successful in reversing the process in all cases. Anemia, multiple gestation, and excessive intravenous fluids were identified as possible risk factors.