Should We Add Clonidine to Local Anesthetic for Peripheral Nerve Blockade? A Qualitative Systematic Review of the Literature

BACKGROUND AND OBJECTIVES: Although clonidine has been shown to prolong analgesia in central neuraxial blocks, its use in peripheral nerve blocks remains controversial. We performed a systematic review of the current literature to determine the benefit of adding clonidine to peripheral nerve blocks. METHODS: A systematic, qualitative review of double-blind randomized controlled trials on the benefit of clonidine as an adjunct to peripheral …