Abnormal connectivity of the visual pathways in human albinos demonstrated by susceptibility‐sensitized MRI Journal Articles uri icon

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  • We studied activation of the human visual cortex (VC) using susceptibility-sensitized MRI at 1.5 Tesla. Three albinos and six healthy controls underwent a series of monocular and binocular photic flash stimulation. Monocular stimulation in albinos caused predominant contralateral activation with a small, well-delineated area in the anterior part of the VC in the ipsilateral hemisphere. This finding was consistent with a chiasmal crossing anomaly in albinism. All controls had symmetric patterns of activation during monocular stimulation. Functional MRI represents a promising method for evaluation of the visual pathways in humans.


  • Hedera, P
  • Lai, S
  • Haacke, Mark
  • Lerner, AJ
  • Hopkins, AL
  • Lewin, JS
  • Friedland, RP

publication date

  • October 1994