Improved sensitivity of proton MR to oxygen‐17 as a contrast agent using fast imaging: Detection in brain

AbstractThe potential utility of H217O as a contrast agent has been demonstrated in biological solutions and isolated tissues but its use has been impaired by the need to run heavily T2‐weighted spin‐echo images. By choosing an appropriate steady‐state free precession experiment sensitive to T1/T2, we have improved the available contrast‐to‐noise. per unit time by more than a factor of 5. This allows easy measurement of the proton effects for concentrations as low as 0.4% H217O in less than 1 min. Injection into small animals produces a marked reduction in the overall image intensity. Consecutive imaging at the rate of one every 52 s has been used to follow the rate of change in brain image intensity immediately after injection. © 1988 Academic Press, Inc.

Improved sensitivity of proton MR to oxygen‐17 as a contrast agent using fast imaging: Detection in brain Journal Articles