Benchtop fabrication of multi-scale micro-electromagnets for capturing magnetic particles

Micro-electromagnets hold great promise for integration into portable and handheld lab-on-a- chip systems applicable to point-of-care disease management. Two major requirements must be satisfied in order for such devices to be applicable into practical, miniaturized, and portable biomedical instrumentation: low power operation and low-cost fabrication. In this paper, we use numerical modeling combined with a lithography-free fabrication process to create micro-electromagnets on a polymer substrate. Numerical modeling reveals that active-passive devices—ferromagnetic layers coupled with current-controlled planar coils—are essential for generating a sufficient magnetic force for magnetic particle manipulation at low currents (<50 mA). In addition, it is shown that current carrying conductors created from micro/nanotextured materials further enhance the generated magnetic force at a given current. To combine low-cost fabrication with low-current operation, we developed a benchtop fabrication method based on craft cutting, polymer induced thin film wrinkling, and electrodeposition to create a multilevel arrangement of multi-scale materials essential for low-current operation. We demonstrate that the fabricated active-passive devices featuring wrinkled copper active layers and permalloy passive layers capture 2.8 μm magnetic particles upon the application of a 35 mA current.

Benchtop fabrication of multi-scale micro-electromagnets for capturing magnetic particles Journal Articles