Concomitant information in bioassay and semi-parametric estimation Academic Article uri icon

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abstract

  • This paper presents a flexible modern approach to handling concomitant information for estimating the relative potency parameter in quantitative bioassays. This is accomplished in a semi-parametric framework where the concomitant variable is included non-parametrically. Estimation is then performed using smoothing splines where the point and interval estimators of the relative potency parameter exhibits desirable asymptotic properties.

publication date

  • May 15, 2005