Journal article
Dopamine D4 receptor variant, D4GLYCINE194, in Africans, but not in Caucasians: No association with Schizophrenia
Abstract
Because antipsychotic drugs selectively block dopamine receptors and since dopamine D4 receptors are elevated sixfold in postmortem schizophrenia brain, we searched for possible abnormalities in the coding region of the genomic DNA sequence for the dopamine D4 receptor in control and schizophrenia tissues. The DNA sequence for the first 250 bases of exon 3 of this receptor was examined in the genomic DNA from 296 control individuals and 58 …
Authors
Seeman P; Ulpian C; Chouinard G; Van Tol HHM; Dwosh H; Lieberman JA; Siminovitch K; Liu ISC; Waye J; Voruganti P
Journal
American Journal of Medical Genetics, Vol. 54, No. 4, pp. 384–390
Publisher
Wiley
Publication Date
December 15, 1994
DOI
10.1002/ajmg.1320540419
ISSN
0148-7299
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAfricaAmino Acid SequenceBase SequenceBlack PeopleBrainDNAExonsFemaleGenetic VariationGlycineHumansMaleMiddle AgedMolecular Sequence DataOligodeoxyribonucleotidesPolymerase Chain ReactionPrevalenceProtein Structure, SecondaryReceptors, DopamineReceptors, Dopamine D2Receptors, Dopamine D4Repetitive Sequences, Nucleic AcidSchizophreniaWhite People