Journal article
Transcriptional Activation by DNA-Binding Derivatives of HSV-1 VP16 That Lack the Carboxyl-Terminal Acidic Activation Domain
Abstract
The herpes simplex virus transactivator VP16 directs the assembly of a multicomponent protein-DNA complex with cellular components Oct-1 and VCAF-1, contributing a potent carboxyl-terminal acidic activation domain that is essential for activation of gene expression in mammalian cells. We show here that VP16, devoid of this acidic activation domain, functions as a strong transcriptional activator in the yeast Saccharomyces cerevisiae when …
Authors
Popova B; Bilan P; Xiao P; Faught M; Capone JP
Journal
Virology, Vol. 209, No. 1, pp. 19–28
Publisher
Elsevier
Publication Date
May 1995
DOI
10.1006/viro.1995.1227
ISSN
0042-6822
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBase SequenceCell LineDNA ProbesDNA, FungalDNA-Binding ProteinsFungal ProteinsGenes, ReporterHeLa CellsHerpes Simplex Virus Protein Vmw65Host Cell Factor C1HumansMolecular Sequence DataMutationOctamer Transcription Factor-1Saccharomyces cerevisiaeSpecies SpecificityTrans-ActivatorsTranscription FactorsTranscriptional Activation