Journal article
Aryl hydrocarbon receptor antagonists attenuate the deleterious effects of benzo[a]pyrene on isolated rat follicle development
Abstract
It has been shown that benzo[a]pyrene, a key component of cigarette smoke and an aryl hydrocarbon receptor (AhR) ligand, reduced growth of isolated rat follicles in vitro. However, the mechanism underlying the induced changes in folliculogenesis is unknown. This study proposed that the reported adverse effects of benzo[a]pyrene on follicle growth are mediated through AhR activation. The objective was to investigate the effect of benzo[a]pyrene …
Authors
Neal MS; Tuttle AMM; Casper RF; Lagunov A; Foster WG
Journal
Reproductive BioMedicine Online, Vol. 21, No. 1, pp. 100–108
Publisher
Elsevier
Publication Date
July 2010
DOI
10.1016/j.rbmo.2010.03.025
ISSN
1472-6483