Regulation of glucagon-stimulated production of glucose in rat liver by guanosine 3′,5′-cyclic phosphate Academic Article uri icon

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abstract

  • Exogenous cGMP can inhibit both basal and glucagon-stimulated production of glucose in liver slices from fed rats. Thus, cAMP and cGMP have opposite effects on the production of glucose in rat liver. Acetylcholine, an activator of guanylate cyclase (EC 4.6.1.2) in other systems, also inhibits the glucagon-stimulated production of glucose. No effect on glucose production was observed with secretin or exogenous GTP.

publication date

  • December 1976