Journal article
Risk Factors for Airway Remodeling in Asthma Manifested by a Low Postbronchodilator FEV1/Vital Capacity Ratio
Abstract
Airway remodeling may lead to irreversible loss of lung function in asthma. The impact of childhood asthma, airway responsiveness, atopy, and smoking on airway remodeling was investigated in a birth cohort studied longitudinally to age 26. A low postbronchodilator ratio of forced exhaled volume in 1 second (FEV1) to vital capacity (VC) at age 18 or 26 was used as a marker of airway remodeling. "Normal" study members with no history of asthma …
Authors
Rasmussen F; Taylor DR; Flannery EM; Cowan JO; Greene JM; Herbison GP; Sears MR
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 165, No. 11, pp. 1480–1488
Publisher
American Thoracic Society
Publication Date
June 1, 2002
DOI
10.1164/rccm.2108009
ISSN
1073-449X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAdultAge DistributionAge of OnsetAsthmaBiomarkersBronchial HyperreactivityBronchodilator AgentsCase-Control StudiesChildCohort StudiesFemaleForced Expiratory VolumeHumansLongitudinal StudiesMalePatch TestsPredictive Value of TestsPrevalenceProbabilityReference ValuesRespiratory Function TestsRisk FactorsSensitivity and SpecificitySeverity of Illness IndexSex DistributionVital Capacity