Journal article
Deoxyribozymes: New players in the ancient game of biocatalysis
Abstract
The repetitive and extraordinarily stable polynucleotide chains of DNA serve as an ideal storage system for genetic information. Although it is best known for its helical structure and relatively inert character, in vitro selection can be used to compel DNA to perform a surprising variety of chemical reactions. These artificial DNA enzymes or 'deoxyribozymes' generate large chemical rate enhancements and demonstrate precise substrate …
Authors
Li Y; Breaker RR
Journal
Current Opinion in Structural Biology, Vol. 9, No. 3, pp. 315–323
Publisher
Elsevier
Publication Date
June 1999
DOI
10.1016/s0959-440x(99)80042-6
ISSN
0959-440X