Increased expression of nitric oxide synthase in human lung transplants after nitric oxide inhalation1

BACKGROUND: The effects of the ischemia-reperfusion process of organ transplantation on nitric oxide (NO) synthase (NOS) in humans are unknown. The effects of NO inhalation on endogenous NOS expression and activity are controversial. The authors hypothesized that NO inhalation may affect ischemia-reperfusion-induced alterations of the endogenous NOS system. METHODS: The authors performed lung biopsy on patients in a randomized phase II clinical …