Journal article
The Approach to Heparin-Induced Thrombocytopenia
Abstract
Heparin-induced thrombocytopenia (HIT) is a prothrombotic drug reaction caused by platelet-activating antibodies that recognize multimolecular complexes of platelet factor 4 (PF4) bound to heparin. HIT is an intense hypercoagulability state (increased thrombin generation in vivo) that is complicated more often by venous thromboembolism (deep vein thrombosis, pulmonary embolism) than by arterial thrombosis. HIT is a risk factor for …
Authors
Linkins L-A; Warkentin T
Journal
Seminars in Respiratory and Critical Care Medicine, Vol. 29, No. 1, pp. 066–074
Publisher
Thieme
Publication Date
February 2008
DOI
10.1055/s-2008-1047564
ISSN
1069-3424