Journal article
Antiphospholipid syndrome
Abstract
The antiphospholipid syndrome causes venous, arterial, and small-vessel thrombosis; pregnancy loss; and preterm delivery for patients with severe pre-eclampsia or placental insufficiency. Other clinical manifestations are cardiac valvular disease, renal thrombotic microangiopathy, thrombocytopenia, haemolytic anaemia, and cognitive impairment. Antiphospholipid antibodies promote activation of endothelial cells, monocytes, and platelets; and …
Authors
Ruiz-Irastorza G; Crowther M; Branch W; Khamashta MA
Journal
The Lancet, Vol. 376, No. 9751, pp. 1498–1509
Publisher
Elsevier
Publication Date
October 2010
DOI
10.1016/s0140-6736(10)60709-x
ISSN
0140-6736