Journal article
Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists
Abstract
Prothrombin complex concentrates (PCCs) are recommended as the treatment of choice in warfarin-related coagulopathy. However, the risk of thromboembolic complications associated with their use is not well defined. We performed a meta-analysis to estimate the rate of thromboembolic complications in patients receiving vitamin K antagonists (VKAs) treated with PCCs for bleeding or before urgent surgery. Medline and Embase databases were searched. …
Authors
Dentali F; Marchesi C; Giorgi Pierfranceschi M; Crowther M; Garcia D; Hylek E; Witt DM; Clark NP; Squizzato A; Imberti D
Journal
Thrombosis and Haemostasis, Vol. 106, No. 03, pp. 429–438
Publisher
Thieme
Publication Date
2011
DOI
10.1160/th11-01-0052
ISSN
0340-6245