Combined measurements of N-terminal pro-brain natriuretic peptide and cardiac troponins in potential organ donors Academic Article uri icon

  •  
  • Overview
  •  
  • Research
  •  
  • Identity
  •  
  • Additional Document Info
  •  
  • View All
  •  

abstract

  • OBJECTIVE: Brain death may induce cardiac dysfunction. In potential organ donors measurements of N-terminal pro-brain natriuretic peptide (NT-proBNP) and circulating cardiac troponins T and I (cTnT and cTnI), alone or in combination, are performed to investigate the accuracy of these biomarkers for early diagnosis of left ventricular systolic dysfunction. DESIGN AND SETTING: Prospective study in a multidisciplinary intensive care unit of an university hospital. PATIENTS: 63 brain-dead patients scheduled for multiple organ harvesting. MEASUREMENTS AND RESULTS: We measured NT-proBNP, cTnT, and cTnI and determined fractional area change (FAC) using transesophageal echocardiography. Forty-five patients had normal FAC, 9 a moderate decrease in FAC (30-50), and 9 a severe decrease in FAC (

authors

  • Nicolas-Robin, Armelle
  • Salvi, Nadège
  • Medimagh, Sassi
  • Amour, Julien
  • Le Manach, Yannick Arnaud
  • Coriat, Pierre
  • Riou, Bruno
  • Langeron, Olivier

publication date

  • June 2007