Role of glial-like type II cells as paracrine modulators of carotid body chemoreception

Mammalian carotid bodies (CB) are chemosensory organs that mediate compensatory cardiorespiratory reflexes in response to low blood PO₂ (hypoxemia) and elevated CO₂/H⁺ (acid hypercapnia). The chemoreceptors are glomus or type I cells that occur in clusters enveloped by neighboring glial-like type II cells. During chemoexcitation type I cells depolarize, leading to Ca²⁺-dependent release of several neurotransmitters, some excitatory and others …